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An amount of 9-iodo-minocycline (200g, 343mmol), tetrakis(triphenylphosphine) palladium (0) (97mg, 034mmol), zinc cyanide (500mg, 417mmol) were loaded in anhydrous DMF (20mL) in a dry 20mL microwave reaction vessel equipped with a magnetic stirring bar.
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Additionally, there was a significantly higher number of patients who discontinued therapy due to adverse reactions, including hypotensive symptoms (48% vs!
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